Dr. Jorge Romero and Dr Luigi Di Biase received multi-million dollar grant to conduct the investigator initiated study “Posterior Wall and/or Left Atrial Appendage Empiric Electrical Isolation for Non-Paroxysmal Atrial Fibrillation trial (The PLEA Trial)

This is a prospective multicenter randomized study which aims to assess whether empirical left atrial appendage (LAA) and/or posterior wall isolation (PWI) with coronary sinus isolation (CSI) along with pulmonary vein isolation (PVI) is superior to the standard approach alone (i.e. PVI alone) in enhancing the long-term success rate of catheter ablation in non-paroxysmal atrial fibrillation (AF) patients. Primary Endpoint: Freedom from documented AF/AT/AFL episodes (> 30 seconds) at 12 months after one ablation procedures without antiarrhythmic medications after blanking period (3 months after ablation).